Amphetamine is thought to inhibit monoamine oxidase, whereas the power of amphetamine and its metabolites to inhibit different P450 isozymes along with other enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes reveal minor inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4 b